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Description
This supplement is safe when used daily for up to 2 months

Histamine Synthesis and Functions Decarboxylation of histidine in the intestine by bacteria gives rise to histamine
All mice were housed under controlled conditions (temperature: 22C 2C

Because it's applied to the skin rather than swallowed, this article doesn't classify it as a dietary supplement - that's a determination best confirmed directly with the brand

M., & Agarwal, V