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The observation that the activation of 1 integrins by scTS2/16 in leukocytes extends to epithelial organoid cells opens a range of applications

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The rest of the E peptide is encoded by exon 5 (Eb), exon 6 (Ea) or an insert from exon 5 (49 bp in humans, 52 bp in rodents) spliced onto exon 6 (Ec)

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The potential for drug interaction with this single enzyme, coupled with the wide interindividual differences in enzymatic activity, generates some level of risk in administration of high doses and multiple drugs as well as food-drug and herb-drug interactions