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Description
It was previously shown that TP53 disrupts the intramolecular interaction of the Forkhead (FH) domain and the conserved region 3 (CR3) of human FOXO3 (Fig

By disrupting this interaction, FOXO4-DRI has been studied for its ability to selectively induce programmed cell death in senescent cells while leaving healthy cells unaffected in preclinical research models

The goal is to avoid repeatedly irritating the same tissue and to make it easier to notice reactions

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Long-term potentiation is associated with new excitatory spine synapses on rat dentate granule cells
