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In comparison, patients who used retatrutide (8 mg and 12 mg once weekly) lost 17.5% at 24 weeks and 24.2% of their body weight after 48 weeks in phase 2 clinical trials

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However, studies investigating their effectiveness in aging remain inconclusive, as ROS also play essential physiological roles, including functioning as signaling molecules

Bibcode:2018TEcoE..33..958B