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Fondaparinux (antithrombin activator) and the direct thrombin inhibitor drugs including hirudin and bivalirudin significantly inhibited procoagulant activity of hepatocytes in vitro (Stephenne et al., 2012)
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doi: 10.1093/jn/134.3.489 53 ZhaoT.LiuY
While the mechanism is plausible, the evidence does not yet exist to say what it does in people, at what dose, for what problem, or in which populations, especially in women
doi: 10.1105/tpc.13.5.993 11 BriggsW
