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Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth

HIF-1 upregulates glycolysis-related enzymes and suppresses mitochondrial fatty-acid oxidative pathways (e.g., by reducing PPAR-mediated -oxidation capacity), thereby promoting a shift from lipid-derived fuels toward greater dependence on glucose-based energy production ( Notably, a systematic review suggested that, at the same relative exercise intensity, short-term hypoxia does not significantly alter the relative contributions of carbohydrate and fat to energy provision (mean difference in respiratory exchange ratio of only 0.01, p = 0.45)

Der VLDL-Spiegel scheint ebenfalls nicht beeinflusst zu werden

doi: 10.1016/j.ymgme.2011.01.011