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doi: 10.1182/blood-2017-10-809293 107 LiuYZhangLWangLTangXWanSHuangQet al

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For ankle injuries specifically, subcutaneous injection near the affected area at 0.25 to 0.50 mg daily for 4 to 8 weeks represents the most common protocol among researchers and biohackers

There hasnt been extensive research on vitamin B12 to treat sciatica, but at least one study has shown promising results
