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A new review in Gastroenterology & Endoscopy News takes a closer look at this evolving relationship

Cambridge University Press

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Activation of the nuclear factor erythroid-2 related factor-2 (Nrf2) pathway involves the transcription of multiple (antioxidant) proteins, including heme oxygenase 1 (HO-1) and NAD(P)H: quinone oxidoreductase 1 (NQO-1), which protect cells from ROS- and cytokine-induced damage and cell death

ROS generation in the cell has the potential to harm lipids, proteins, and DNA