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Augmented therapeutic potential of glutaminase inhibitor CB839 in glioblastoma stem cells using gold nanoparticle delivery

In addition, HBOT increases the levels of key vascular and neuronal growth signaling molecules, such as VEGF, VEGFR-2, Raf-1, MEK1/2, and phospho-ERK 1/2 protein, suggesting that it may bolster neurogenesis and angiogenesis through VEGF/ERK signaling (29, 31, 32)

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4C), NSBSO treated 4T1 cells exhibited shrunken mitochondria with decreased mitochondria cristae, morphological changes from ellipsoid to spheroid, accompanied with damage of mitochondria (Fig

reported that DMSO also can block Na + channel activation The Na + channel is activated by the physical impact on the brain tissue in TBI which leads to initiation of action potential and loss of membrane permeability culminating in necrosis and free radical generation (Huang et al., 2014