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Description
Acta 1822 , 729736 (2012)
In the context of sepsis, GSH plays a multifaceted role in counteracting the oxidative stress and mitochondrial dysfunction that underlie organ failure and systemic inflammation
It activates the transcription of the leucine zipper by binding to the antioxidant response element (ARE) within the promoter of the target genes
Once oxidised, the compound cannot be restored
Filsuvez won approval based on data from the Phase III EASE study, where the drug led to accelerated wound healing, along with a reduction in overall wound burden and less pain associated with changing wound dressings
