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While individual sensitivity varies, caffeine has a half-life of approximately 5 to 6 hours, meaning half of the caffeine from an afternoon coffee remains in your system at bedtime

Studies have shown that reduced selenium levels lead to the accumulation of lipid peroxides, which increase the activity of AP-1, and then upregulate the expression of VEGF and interleukin-8, thereby accelerating the growth of hepatocellular carcinoma cells (119)

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doi: 10.1038/s42255-022-00700-y

Sirtuin 1 regulates mitochondrial biogenesis and provides an endogenous neuroprotective mechanism against seizure-induced neuronal cell death in the hippocampus following status epilepticus