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Description
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The PCD during HR is characterized as non-autolytic and is often shown to be preceded by influx of calcium into the cytoplasm, activation of a MAPK signalling cascades, production of reactive oxygen intermediates and nitric oxide, and biosynthesis of SA [166]

In a model induced by repeated Brucella antigen injections, hippocampal atrophy was accompanied by reduced DG neurogenesis, increased granule-cell apoptosis, and decreased BDNF expression (Moriya et al., 2011)

Evidence-Base Disclosure The published evidence base for IGF-1 LR3 consists predominantly of preclinical research animal models (often rats or mice) and in vitro cell-culture experiments

(Berlin: Springer), 269290
