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In the hippocampus and substantia nigra of male rats, castration-induced androgen deficiency was closely associated with decreased expression levels of mitochondrial MFN2, OPA1, mitochondrial complex I/III activity, and ATP production (107)

Selenium supplementation reduces fasting plasma glucose (FPG), cholesterol, insulin, and TC levels (37)

SBMA on the other hand is caused by expansion of polyglutamine (CAG) repeats in the NTD and is associated with both loss and gain of AR function and results in progressive degradation of motor neurons, causing muscle weakness [31, 32]

The Role of Hepatokines in Metabolism

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