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Consider what happens when tissue is injured: the immediate area often experiences reduced blood flow due to damage to existing vessels

On the other hand, a disposition tells you exactly what happened on a given charge

[DOI] [PMC free article] [PubMed] [Google Scholar] 97

Sampathkumar K, Rajiv A, Sampathkumar D (2016) Analgesic nephropathya painful progression
Approximately one in six patients (up to ~16 %) experience localized reactions at the injection site
