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Melatonin in animal models

Breast Cancer Previous cell-based and human studies have indicated that sulforaphane exposure is associated with decreased breast cancer progression, including initiating cell cycle arrest and apoptosis (Kuran et al., 2020)

[DOI] [PubMed] 179.Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, et al

Elevated M2 macrophage polarization markers have been observed in the lung tissues of patients with idiopathic PH [98-100], and an imbalance in the M1/M2 macrophage ratio is considered a key mechanism driving PH development

Furthermore, sleep regulation is also governed by the circadian timing system, specialized neural circuits dedicated to the homeostatic control of sleep, and the neuroendocrine system (Yin et al