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To overcome these shortcomings, alternative UPS inhibitors have been searched for in many fields

These elements are crucial as they can transcribe the expression of MTs, particularly by minimizing ROS-mediated cytotoxicity, thus adding another layer of protection against arsenics harmful effects

With cuprizone exposure, the recruitment of T-cells to the lesion site [70] may result from the decreased BBB integrity induced by cuprizone [75, 76] Cuprizone toxicity produces profound demyelination in the white and grey matter of the brain that mirrors sites of MS pathology [46]

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