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The authors would like to thank Vaishali Chudasama for early support of the AMG 966 clinical development program, Darren Bates and Zhulun Wang for assistance with reagents for in vitro T cell assays, Qingchun Zhang, Nic Angell and Greg Barnett for assistance with SEC-MALS experiments, Fanching Lin for technical assistance with the TL1A assay, Richard Hu for assistance with biomarker analysis, and Shalini Gupta and Marta Starcevic-Manning for support of immunoassay and domain characterization experiments