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Their presence in seminal plasma contributes to the oxidative environment within the male reproductive system

This substrate functions as an inhibitor of the enzyme succinate dehydrogenase, promotes succinate accumulation, stabilizes HIF-1, and decreases mitochondrial respiration, leading to more ROS

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95 Elevated ROS levels can induce apoptosis in both osteoblast precursor cells and mature osteoblasts, while simultaneously suppressing the expression of osteogenic markers including alkaline phosphatase (ALP), osteocalcin (OCN), and RUNX2, thereby impairing BMSC osteogenic differentiation (Fig

Glutathione and Signal Transduction in the Mammalian CNS. Journal of Neurochemistry 73: 889902