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Description
Defective hypothalamic growth hormone (GH)-releasing hormone activity may contribute to declining GH secretion with age in man

The inhibition of sphingolipid biosynthesis disrupts numerous cell functions and signaling pathways, including apoptosis and mitosis, thus potentially contributing to carcinogenesis through an altered balance of cell death and replication [113]

Inactivation is due to loss of one histidine residue

Xu DD, Wang Y, Zhou PJ, Qin SR, Zhang R, Zhang Y, Xue X, Wang J, Wang X, Chen HC, et al

Requires consistent and long-term application