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Multiple pharmacological inhibitors, including S-p-bromobenzyl-glutathione cyclopentyl diester (BBGC), ethyl pyruvate, TER 117 and curcumin, have been shown to sensitize cancers to chemotherapy [121, 244, 245]

In any case, the most acknowledged cytoplasmic protein able to regulate NRF2 by promoting its stability and nuclear role is p62 [196]

The IGF signaling pathway has also been implicated in resistance to current therapeutic strategies, including ER and HER2 targeting drugs

[DOI] [PMC free article] [PubMed] [Google Scholar] 178.Van Zuiden M., Frijling J.L., Nawijn L., Koch S.B., Goslings J.C., Luitse J.S., Biesheuvel T.H., Honig A., Veltman D.J., Olff M