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Conclusion This work compared the metabolic profile of the MDA-MB-231 parental cDDP-sensitive cell line (time course up to 48 h) with that of a derived cDDP-resistant line, the latter characterized by a more than onefold larger IC 50 (for cDDP at 48 h), higher number of PGCCs, a slighter higher activation of the NF-B pathway along with about 50% decrease in the ERK pathway activation

However, they do not reach deeper pigment layers, so their effect on long-standing discoloration is usually limited

Three authors (MFMS, SB, AAK) scanned the repository of articles for trial selection from the titles and abstracts derived from the searches

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