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Sohei Kimoto, Wakayama Medical University, Japan Updates Copyright 2023 Fujihara

Choline may raise blood levels of TMAO, a compound that may advance atherosclerosis (hardening of the arteries) by reducing the normal clearing of cholesterol and may increase plaque instability (which can cause it to become dislodged) (Koay, Cardiovasc Res 2020), although there do not appear to be studies assessing the link between citicoline (the form of choline in Cognizin ) and TMAO

2023 Mar 27;15(7):1620

doi: 10.1016/j.nbd.2018.09.020 64 GauthierS.AlbertM.FoxN.GoedertM.KivipeltoM.Mestre-FerrandizJ.et al
The combination can also consist of hyaluronic acid or any therapeutic agent used
