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Additionally, NNMT has been shown to play a causal role in the development of T2D through quantitative trait locus mapping in mice (Yaguchi et al., 2005)

Bokov AF, Garg N, Ikeno Y, Thakur S, Musi N, DeFronzo RA, Zhang N, Erickson RC, Gelfond J, Hubbard GB, Adamo ML, Richardson A

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Myoblasts are thought to be precursor muscle cells, and C2C12 cells are a type of murine model muscle cell line

These findings suggest that NNMT may represent a promising therapeutic target for the development of RNAi drugs aimed at preventing or treating MetS (Van Haren et al., 2021
