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Our extensive understanding of the physical organic chemistry of Michael addition reactions leads to the second generation RT GSH probe
This strategy must consider the potential adverse effects of serine depletion and may not be suitable for all patients, particularly those with cachexia or in pediatric populations 159
10.1021/acs.jproteome.0c00314 J
Compound 38 can also be reduced to amine 40 , which facilitates the attachment of the linker to the carboxylic acid terminal via the formation of an amide bond (41) (Scheme 6) 81,83
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