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In addition, increased HLA-II expression can lead to increased presentation of native cellular autoantigens or viral antigens, which can undergo posttranslational modifications, such as citrullination, and form neoantigens, through the endogenous antigen processing pathway, triggering the activation of autoreactive cells [171, 212,213,214,215]

Furthermore, we have identified Lys159, as critical for phosphoinositide binding (Fig

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