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The cooling hydrogel patches hug the contours of the eye area to help deliver these ingredients while providing a soothing, de-puffing effect in as little as 10 minutes

doi: 10.1186/s12937-018-0331-4 20

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7.5 Improving OSC bioavailability: delivery system design One of the major practical barriers to clinical translation of many OSCs is their poor bioavailabilitydue to instability (e.g., rapid degradation of thiosulfinates), poor aqueous solubility, susceptibility to first-pass metabolism, and limited systemic exposure