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13,31 Patients with fibromyalgia have reduced opioid-mediated descending nociceptive modulation with reduced numbers of available central -opioid receptors and higher levels of endogenous opioids in the cerebrospinal fluid

doi: 10.1055/s-2007-979169

Crystals form when levels exceed the bodys ability to metabolise uric acid, which can result in either gout or kidney stones depending on where they form

& McArthur, J

The reason this ingredient is so effective is because it forms a thin film on the skin that reduces transepidermal water loss (TEWL) while supplying linoleic acid to the stratum corneum to improve barrier strength