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Large-scale studies have yet to demonstrate a direct causal link between B12 injections and significant weight loss
Active cancer care, history of Leber hereditary optic neuropathy (a rare B12 issue), or unexplained anemia with neurologic symptoms warrant clinician evaluation before selfsupplementing
A study has found that short-term sleep deprivation can indirectly affect human microbiota by altering the balance between Firmicutes and Bacteroidetes , with the ratio of these bacteria doubling after just two days of partial sleep deprivation compared to normal sleep conditions [208]
For athletes seeking both recovery and performance improvements, applying cryotherapy 1-2 hours after training (rather than immediately) may preserve these beneficial effects while still providing anti-inflammatory benefits
Of further importance is the well-known effect of exercise in IGF-1 plasma level rise
