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This binding inhibits NF-B signaling, reduces the production of pro-inflammatory cytokines (TNF-, IL-6), and promotes the differentiation of regulatory T cells (Tregs), which are essential for maintaining immune tolerance and suppressing excessive inflammation

Specific membrane and nuclear receptors have been recognized for melatonin in nonneural tissues from many different species [20]

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[DOI] [PMC free article] [PubMed] [Google Scholar] Pilkington E.H., Suys E.J.A., Trevaskis N.L., Wheatley A.K., Zukancic D., Algarni A., Al-Wassiti H., Davis T.P., Pouton C.W., Kent S.J., Truong N.P

The small intestine is not designed to absorb whole proteins