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A differential metabolomics study suggests that the depletion of glutathione after low dose APAP (150mg/kg) is paralleled by elevation in the glutathione analogue ophthalmic acid, where the SH group of the cysteine residue of GSH is replaced with a CH3 group from 2-aminobutyrate [21]
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Perhaps most significant for neuropathy patients was the finding on autotomy behavior
Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance
doi: 10.1016/j.abb.2015.12.006
