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Furthermore, animal and clinical studies have shown that glutamine deficiency leads to villous atrophy (destruction of villi) and mucosal ulcerations (sore lesions) in the small intestine, leading to an impairment in the functioning of immune cells, and resulting in greater susceptibility to infections

Furthermore, in prostate cancer cells, miR-185 and miR-342 control lipogenesis and cholesterogenesis by reducing the expression of SREBP-1/2 and downregulating their targeted genes, including fatty acid synthase 96

Importantly, when researchers blocked TGF- signaling, the pro-bone benefits of MOTS-c were diminished, confirming that the TGF-/Smad pathway is crucial to MOTS-cs action in bone

Capone et al., Figure 1 On the other hand, peripheral factors involve local muscle activation (Kluger et al., 2013)

Berndt, N