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Previous reports have proposed that selenomethionine may be metabolized through either the methionine salvage pathway or the methionine cleavage pathway (Fig

Lamolet B, Pulichino AM, Lamonerie T, Gauthier Y, Brue T, Enjalbert A et al (2001)

Exosomal escape mechanisms have also been harnessed to deliver CRISPR-Cas9 complexes into resting CD4 T cells, enabling proviral DNA excision with higher efficiency and reduced cytotoxicity compared to standard polymeric carriers

As the previous paragraph shows, glutathione supplementation can help prevent deficiency

Consideration The requirements for assessing the genotoxicity of pharmaceuticals differ between small molecule drugs and biotherapeutics