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Through in vivo and in vitro experiments in PAH rat models, it was found that HIF-1 can regulate mitochondrial dynamics in pulmonary vascular remodeling under hypoxic conditions by directly regulating the expression of dynamin-related protein 1 (Drp1), which in turn can cause hypoxia-induced mitochondrial dysfunction and hypoxia-stimulated PASMCs proliferation and apoptosis, that is, mitochondrial dynamics under hypoxic environment are involved in the remodeling of pulmonary vessels [56]

The limited number of qualifying curcumin studies reveals essential trends in current research directions

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Second, in the private healthcare system, the mean age was 47 years (Figure 3B)