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these were not completed in peer-reviewed form, and a Phase I safety study has been mentioned in the literature but its results were never published
Effect of mutation type and location on clinical outcome in 1,013 probands with Marfan syndrome or related phenotypes and FBN1 mutations: an international study
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This ensures maximum local concentration [21]
Endocr Rev 16:6386 Korbonits M, Besser M 1996 Diagnosis of growth hormone deficiency in adults
