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Medical Economics Company, Montvale, NJ Polonsky J (1973) Quassinoids bitter principles

This study aims to test the hypothesis that the antioxidant effect of the synthetic tetrapeptide AEDG (Ala-Glu-Asp-Gly, Epitalon) improves the delayed healing process associated with hyperglycemia in DR, using a high glucose (HG)-injured human retinal pigment epithelial cell line (ARPE-19)

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In addition, FASN (fatty acid synthase) and SCD1 (stearoyl-coenzyme A desaturase 1) are crucial for modifying the lipid composition of the cell membrane

Its concentration reflects cellular redox status and capacity to neutralize hydrogen peroxide through GPx