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Estrogen is proposed to exert its effects through activation of the MAP kinase pathway and transcription factor NF-B, leading to increased expression of antioxidant enzymes such as superoxide dismutase (Farhat et al., 2017

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It was also demonstrated that the exposure of lung epithelial cells A549 and L132 to gliotoxin for 24 h resulted in a significant increase in the proportion of cells in S-phase (3039%), with a concomitant decrease in G2/M-phase

Application of inhibitors
