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To view a copy of this licence, visit About this article Cite this article Mahesh, S., Kaskel, F

In addition to these intracellular inflammatory events, the integrity of the bloodbrain barrier (BBB) plays a decisive role in shaping the neuroinflammatory environment in PD [53]

FIGURE 2 The accumulation of methylmalonic acid (MMA) and Hcy because of these disruptions leads to oxidative damage and impaired methylation

Studies such as ACCORD and EDIC have found that improving A1C levels does affect DPN progression and that intensive treatment caused a delay in the progression of neuropathy and reduced Michigan Neuropathy Screening Instrument score, loss of ankle jerks, and loss of light touch at the end of the study

doi: 10.1016/j.blre.2017.06.002 80 BatoolTMakkyEAJalalMYusoffMM