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Description
Largest impairment risk
Evidence includes: Stimulation of endothelial and keratinocyte migration Enhanced blood vessel density in wound healing models Promotion of stem cell differentiation toward repair cell lineages Low molecular weight enabling tissue penetration over long distances Unlike growth factors that bind to extracellular matrix, TB-500s mobility allows systemic distribution to multiple injury sites

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This angiogenic effect appears to work through the upregulation of vascular endothelial growth factor (VEGF) and other growth factors critical for tissue repair
