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Senolytic Effects The landmark study by Yousefzadeh et al

Electroanalysis 30 , 13571362 (2018)
doi: 10.1093/nar/gky006 91 SterlinDVelascoGMoshousDTouzotFMahlaouiNet al

Sym004 also demonstrated efficacy in cetuximab-resistant CRC xenograft models harboring mutations in EGFR, S492R EGFR-mutant DCR7, and G465R EGFR-mutant LIM1215 (Sanchez-Martin et al., 2016)

Instead of targeting GHRH receptors, it binds to Growth Hormone Secretagogue Receptors (GHS-R1a) , commonly known as ghrelin receptors
