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Can Res 62(19):54765484 Jaffe GJ et al (2016) A phase 1 study of intravitreous E10030 in combination with ranibizumab in neovascular age-related macular degeneration

The fact that cerebrolysin, which promotes angiogenesis through VEGF upregulation, shows benefit in this specific condition aligns with its known mechanisms

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These shifts disrupt metabolic balance, potentially leading to inflammation in systemic and adipose tissues, possibly due to the translocation of microbial metabolites and insulin resistance