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Description
Biphasic modulation of NOS expression, protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock: downstream regulation of COX2, IL1 , TNF , IL6, and HMGB1 expression

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This issue, however, was rekindled and became a subject of debate with the 1996 approval by the US FDA of mandatory folic acid fortification of staple food products for the prevention of neural tube defectaffected pregnancies (13)

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