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This reduction in immunogenicity not only improves the safety profile of these peptides but also enhances their potential for clinical applications, particularly in chronic treatments where long-term exposure to the peptide may otherwise elicit immune responses316, 317, 318, 319
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10.1016/j.yrtph.2006.05.006 79 HauserW
As a result, the rapid metabolism leads to an unexpected decrease in the drug concentration and, thereby, to a therapeutic failure [59]
