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In addition, aortic and plasma levels of the isoprostane iPF 2 -III, a marker of oxidative stress and lipid peroxidation, were elevated in the GPx1 deficient mice [39, 71]

In a study on myocardial IRI in diabetic rats, NAC alleviated ferroptotic cell death and oxidative injury[148]

As a result of these very promising results in animal models, several studies have evaluated the potential of anti-oxidative stress therapies in clinical settings (203, 204)

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Carnosine (-alanyl-L-histidine) and related peptides are present in muscle and brain at millimolar concentrations