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The five most upregulated genes in astrocytes were HMGB1, HSPH1, PTGES3, SLC7A11 and HSPA4L, while the five most downregulated genes were ANGPTL4, ETNPPL, SLC4A4, SLC6A11 and LINC00499 (Fig

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Additionally, selenium supplementation increased the risk of one type of skin cancer (squamous cell carcinoma) by 25%

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