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The ChaC family of -glutamyl cyclotransferases is required for Leishmania to switch to a slow growth state and for long-term survival of the parasite

As a matter of fact, this protective effect is achieved through the regulation of GSH metabolic pathways, prevention of DNA damage, control of cell proliferation and survival, as well as inhibition of angiogenesis and metastasis [84,85]

4.3 Human evidence, pharmacokinetic limits, and trial design lessons Human clinical evidence remains limited and underpowered

Ellman's method is still an appropriate method for measurement of cholinesterases activities

Zhang, H., Go, Y.-M