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Its relevance to sleep centers on two properties: Selective GH release without cortisol elevation

Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27(Kip1)

In menstruating individuals, that can translate to irregular cycles, anovulation, or luteal phase defects
Quantitative assessment of tissue iron by MRI scan is useful in these circumstances

Excess of glucocorticoid induces cardiac dysfunction via activating angiotensin II pathway
