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14094) and 13563 direct agencies to assess all costs and benefits of available regulatory alternatives and, if regulation is necessary, to select regulatory approaches that maximize net benefits (including potential economic, environmental, public health and safety effects, distributive impacts, and equity)

This is remarkable because current pharmacological treatments for frozen shoulder are entirely palliative

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Research in cell culture and rodent models consistently demonstrates that MOTS-c accelerates this translocation independently of insulin, offering a distinct and additive mechanism to insulin sensitizers like Metformin [1]