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The next-best option is mid-afternoon at least four hours post-lunch and two hours before dinner

It acts primarily at the injury site: it upregulates growth hormone receptor expression locally, drives angiogenesis via VEGF, activates the nitric oxide system, and switches on the CREB pathway, the cellular trigger for repair gene expression

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There was general consistency across trials, and the model qualified that primary analyses obtained at day 10 are expected to be valid at steady state