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Each member of the treatment groups received an icv injection of scopolamine hydrobromide (70 nmol in 2 aCSF over a duration of 20 s) 20 min prior to testing followed by Nle'-AnglV or one of the analogs (in 2 aCSF) 5 min prior to testing

If this principle holds broadly, it opens the door to a new paradigm in anti-aging medicine, one based on restoring the body's own regulatory signals rather than overriding them with pharmaceutical agents

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Hypoxia not only manifests as the direct effect of insufficient oxygen supply to tissues, but the microenvironmental disturbances it triggers are often accompanied by significant oxidative stress, constituting a core factor exacerbating pathological damage [5]

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