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There are a number of ways you can do this through diet and lifestyle changes or direct supplementation especially if there is fibrosis involved

Energy Production: By aiding in the transport of fatty acids, L-carnitine helps increase energy production, making it a popular supplement among athletes and those with high physical demands

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In vitamin D-deficient PCOS phenotypes, repletion improves adiponectin/leptin ratios and lowers circulating TNF- and IL-6, reflecting stabilization of the adipokine-microbiota-insulin axis (234)

Moreover, in the adult brain, microglia promote dendritic spine formation through the secretion of brain-derived neurotrophic factor (BDNF)